- Huang DB et al. A Pooled Analysis of the Safety and Efficacy of Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Patients With Intravenous Drug Use: Phase 3 REVIVE Studies. Clinical Therapeutics, 41:6, 1090-1096, 2019.
- Noviello, S. et al. In vitro activity of dihydrofolate reductase inhibitors and other antibiotics against Gram-positive pathogens collected globally between 2004 and 2016. Journal of Global Antimicrobial Resistance. Volume 16, 236-238, March 2019.
- Bryant, AE et al. The effects of iclaprim on exotoxin production in methicillin-resistant and vancomycin-intermediate Staphylococcus aureus. Journal of Medical Microbiology. 2019 Jan 24 [Epub ahead of print].
- Huang, D. et al. Surveillance of iclaprim activity: in vitro susceptibility of Gram-positive skin infection pathogens collected from 2015 to 2016 from North America and Europe. Diagnostic Microbiology and Infectious Disease. 93:2, 154-158, February 2019.
- Huang, D. A pharmacokinetic and pharmacodynamic evaluation of iclaprim activity against wild-type and corresponding thymidine kinase-deficient Staphylococcus aureus in a mouse abscess model. Journal of Medical Microbiology 2018.
- Huang, D et al. Iclaprim Activity against Wild Type and Corresponding Thymidine Kinase Deficient Staphylococcus aureus in a Mouse Protection Model. European Journal of Clinical Microbiology & Infectious Diseases (2018) (In Press).
- Noviello, S et al. Iclaprim: a differentiated option for the treatment of skin and skin structure infections. Expert Review of Anti-infective Therapy, 16:11, 793-803.
- Huang, D et al. Extracellular and Intracellular Activity of Iclaprim Against Listeria monocytogenes. International Journal of Antimicrobial Agents. 53:1, 106-107, January 2019.
- Huang, D et al. Surveillance of iclaprim activity: in vitro susceptibility of Gram-positive skin infection pathogens collected from 2015 to 2016 from North America and Europe. Diagnostic Microbiology and Infectious Disease. 93:2, 154-158, February 2019.
- Patel, N et al. Potential for Cost Saving with Iclaprim Owing to Avoidance of Vancomycin-Associated Acute Kidney Injury in Hospitalized Patients with Acute Bacterial Skin and Skin Structure Infections. Clinical Drug Investigation. 38:10, 935-943, October 2018.
- Huang DB et al. A Pooled Analysis of the Phase 3 REVIVE Trials: Randomized, Double-blind Studies to EValuate the Safety and Efficacy of Iclaprim Versus Vancomycin for trEatment of Acute Bacterial Skin and Skin Structure Infections. Journal of Antimicrobial Agents, August 2018, Volume 52, Issue 2, Pages 233–240.
- Holland, TL et al. A Phase 3, Randomized, Double-Blind, Multicenter Study To Evaluate the Safety and Efficacy of Intravenous Iclaprim versus Vancomycin for Treatment of Acute Bacterial Skin and Skin Structure Infections Suspected or Confirmed To Be Due to Gram-Positive Pathogens (REVIVE-2 Study). Antimicrob Agents Chemother. May 2018 62:e02580-17
- Huang, DB et al. Surveillance of iclaprim activity: In vitro susceptibility of gram-positive pathogens collected from 2012 to 2014 from the United States, Asia Pacific, Latin American and Europe. Diagnostic Microbiology and Infectious Disease. Volume 90, Issue 4, April 2018, pp. 329-334.
- Aliouat, EM et al. In vitro and in vivo activity of iclaprim, a diaminopyrimidine compound and potential therapeutic alternative against Pneumocystis pneumonia. European Journal of Clinical Microbiology & Infectious Diseases. March 2018, Volume 37, Issue 3, pp 409–415.
- Huang, D et al. An Updated Review of Iclaprim: A Potent and Rapidly Bactericidal Antibiotic for the Treatment of Skin and Skin Structure Infections and Nosocomial Pneumonia Caused by Gram-Positive Including Multidrug-Resistant Bacteria. Open Forum Infectious Diseases. Volume 5, Issue 2, 1 February 2018, ofy003.
- Park, JH et al. Identification of the In Vivo Pharmacokinetics and Pharmacodynamic Drivers of Iclaprim. Antimicrobial Agents and Chemotherapy. 2018 Jan 29. pii: AAC.02550-17. [Epub ahead of print].
- Huang, D et al. The effect of pulmonary surfactant on the in vitro activity of Iclaprim against common respiratory bacterial pathogens. Diagnostic Microbiology & Infectious Disease. Volume 90, Issue 1, January 2018, Pages 64-66.
- Huang DB et al. A Phase 3, Randomized, double-blind, multicenter study to EValuate the safety and efficacy of intravenous Iclaprim versus Vancomycin for the trEatment of acute bacterial skin and skin structure infections suspected or confirmed to be due to Gram-positive pathogens: REVIVE-1. Clin Infect Dis. 2018;66:1222-1229.
- Huang DB et al. In Vitro Activity of Iclaprim against Methicillin-Resistant Staphylococcus aureus Nonsusceptible to Daptomycin, Linezolid, or Vancomycin: A Pilot Study. Canadian Journal of Infectious Diseases and Medical Microbiology. Volume 2017 (2017), Article ID 3948626.
- Huang, D et al. Surveillance of Iclaprim Activity: In Vitro Susceptibility of Gram-positive Pathogens Collected from 2012 to 2014 From the United States, Asia Pacific, Latin American and Europe. Diagnostic Microbiology & Infectious Disease. Article in Press.
- Lodise, T et al. Use of Pharmacokinetic and Pharmacodynamic Analyses to Determine the Optimal Fixed Dosing Regimen of Iclaprim for Treatment of Serious Gram-Positive Infections. Antimicrob Agents Chemother. 2017 Nov 13. [Epub ahead of print]
- Huang, D et al. A Phase 2 Randomized, Double-Blind, Multicenter Study to Evaluate Efficacy and Safety of Intravenous Iclaprim Versus Vancomycin for the Treatment of Nosocomial Pneumonia Suspected or Confirmed to be Due to Gram-Positive Pathogens. Clinical Therapeutics. Vol. 39, Issue 8, p1706–1718.
- Krievins D, Brandt R, Hawser S, Hadvary P, Islam K. Multicenter, randomized study of the efficacy and safety of intravenous iclaprim in complicated skin and skin structure infections. Antimicrob Agents Chemother. 2009;53(7):2834-40.
- Oefner C, Bandera M, Haldimann A, et al. Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity. J Antimicrob Chemother. 2009;63(4):687-98.
- Andrews J, Honeybourne D, Ashby J, et al. Concentrations in plasma, epithelial lining fluid, alveolar macrophages and bronchial mucosa after a single intravenous dose of 1.6 mg/kg of iclaprim (AR-100) in healthy men. J Antimicrob Chemother. 2007;60(3):677-80
- Laue H, Valensise T, Seguin A, Hawser S, Lociuro S, Islam K. Effect of human plasma on the antimicrobial activity of iclaprim in vitro. J Antimicrob Chemother. 2007;60(6):1388-90.
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Presentations and Posters
ECCMID 2019
- An efficacy analysis by lesion size of iclaprim versus vancomycin in patients with acute bacterial skin and skin structure infections: pooled phase III REVIVE trials
- Iclaprim versus vancomycin for patients with acute bacterial skin and skin structure infection complicated by Staphylococcus aureus or streptococcal bacteraemia: a pooled analysis of the phase III REVIVE trials
- Surveillance of iclaprim activity against Gram-positive cocci, including antibiotic-resistant strains, collected from patients with skin and skin structure infections during 2017 from European and American hospitals
- Pharmacokinetics of iclaprim by age, weight, race and renal/hepatic function in patients with acute bacterial skin and skin structure infections: phase III REVIVE trials
- Real-world incidence of vancomycin-associated nephrotoxicity in hospitalized patients with acute bacterial skin and soft structure infections
ESCMID/ASM Conference on Drug Development to Meet the Challenge of Antimicrobial Resistance
- State of the Art Lecture: New Antibacterial Agents – Iclaprim
- The Safety of Iclaprim among Diabetic Patients for the Treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI): Pooled REVIVE Studies
- Iclaprim Activity Against Clinical Isolates Causing Acute Bacterial Skin and Skin Structure Infections (ABSSSI) in the Phase 3 REVIVE-1 and REVIVE-2 Studies
- Surveillance of Iclaprim Activity: In Vitro Susceptibility of Drug-Susceptible and Resistant Beta-hemolytic Streptococci Collected During 2012-2016 from Skin and Skin Structure Infections
- Surveillance of Iclaprim Activity: In Vitro Susceptibility of Gram-Positive Skin and Skin Structure Pathogens Collected During 2004-2016
ASM Microbe 2018
- An Analysis of Pooled Efficacy Data from Two Phase 3 Trials of Iclaprim Compared to Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infections
- A Pooled Analysis of Two Phase 3, Randomized, Double-Blind, Multicenter Studies to Evaluate the Safety of Intravenous Iclaprim versus Vancomycin
ECCMID 2018
- A Phase-3, Randomized, Double-blind, Multicentre Study to Evaluate the Safety and Efficacy of Intravenous Iclaprim versus Vancomycin in the Treatment of Acute Bacterial Skin and Skin Structure Infections Suspected or Confirmed to be due to Gram-positive Bacteria
- Potential Cost Savings Opportunities with Targeted Iclaprim (ICL) compared to Vancomycin (VAN) among Hospitalized Patients with Acute Bacterial Skin and Skin Structure Infectious due to Potential Avoidance of VAN-associated Acute Kidney Injury
- Surveillance of Iclaprim Activity: in vitro Susceptibility of Staphylococcus aureus Resistant to Clindamycin/Tetracycline and Beta-haemolytic Streptococci Resistant to Macrolides/ Tetracyclines in Skin and Skin-Structure Pathogens collected during 2015-2016
- Frequency of vancomycin-associated acute kidney injury and healthcare utilization among Veterans’ Affairs patients with skin and skin structure infections
IDWeek 2017
- Effects of Iclaprim and Trimethoprim on Exotoxin Production by Methicillin-resistant Staphylococcus aureus.
- Efficacy Evaluation of Iclaprim in a Neutropenic Rat Lung Infection Model with Methicillin-Resistant Staphylococcus aureus Entrapped in Alginate Microspheres.
IDWeek 2016
- The Use of PK/PD Systems Analyses to Determine the Optimal Fixed Dosing Regimen of Iclaprim (ICL) for a Phase III ABSSSI Clinical Trial.
- Huang, D et al. A 2012–2014 Global Antimicrobial Surveillance of Iclaprim Against Clinical Strains Causing Hospital-Associated Bacterial Pneumonia (HABP) and Skin and Skin Structure Infections (SSSI). IDWeek 2016, October 2016.
IDWeek 2015
- Cessation of Spread of Lesion and Absence of Fever at 72 hours in Complicated Skin and Skin Structure Infection (cSSSI): Reanalysis of the Combined ASSIST Phase 3 Studies Comparing Iclaprim (ICL) and Linezolid (LZD).
- Randomized, Double-Blind, Multicenter Phase II Study to Evaluate Efficacy and Safety of Intravenous Iclaprim versus Vancomycin in the Treatment of Hospital-Acquired, Ventilator-Associated, or Health-Care-Associated Pneumonia Suspected or Confirmed Caused by Gram-positive Pathogens
ICAAC 2008
ICAAC 2007